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PureWay-C® - Vitamin C with Lipid Metabolites

Epidemiological and biochemical studies indicate that vitamin C is important to the optimization of health. Relying on recent research, more health professionals are recommending increased intakes of vitamin C. The optimal intake of vitamin C may not be achieved by diet alone, particularly in groups at high risk for inadequate diet.

PureWay-C is a unique new form of vitamin C that contains ascorbic acid with lipid metabolites and is the most advanced form of vitamin C available. Lipid metabolites are fat soluble compounds that increase vitamin C's function in the body, which enhances the absorption, bioavailability and retention of vitamin C in blood plasma, cells and tissue.

The Science behind PureWay-C
Comparative research studies in vitro and in humans demonstrate that PureWay-C is more rapidly absorbed and leads to higher plasma and cellular levels, having faster and more beneficial effects than ascorbic acid, calcium ascorbate and other ascorbate brands. These benefits include better stimulation of neurite outgrowth, increased fibroblast wound healing activities, increased protection of the immune system from xenobiotic induced inflammatory mechanisms, and greater reduction of plasma levels of C-reactive protein and oxidized LDL, as well as more potent antioxidant and higher free radical scavenging capabilities.

Vitamin C has been implicated in protecting the nervous system from neurodegenerative diseases, the promotion of wound healing and protection from xenobiotic-induced inflammatory damage. As a new vitamin C formulation, PureWay-C is more active and effective than ascorbic acid, calcium ascorbate and other ascorbate brands in all of these areas. The ability of PureWay-C to quickly affect cell behavior is an indication of its rapid cellular uptake and improved activity in providing the benefits of vitamin C supplementation.

Cardiovascular Health
PureWay-C positively impacts human health in numerous ways. As a consequence of enhanced uptake and retention, it has a greater beneficial effect on cardiovascular health. This is determined by a reduction of plasma oxidized low density lipoproteins and C-reactive protein levels after PureWay-C supplementation. In this regard, PureWay-C is the vitamin C ingredient of choice for those seeking the health benefits of vitamin-C supplementation.

Consumption of PureWay-C increases plasma vitamin C as well as decreases oxidative stress and biomarkers of inflammation, which indicates that the protective effect this ingredient may extend beyond its antioxidant capability. C-reactive protein is a marker of inflammation found to be associated with future coronary artery disease (CAD) and cardiovascular risk in a variety of clinical settings. Oxidized low-density lipoproteins are a systematic marker of oxidative stress. Inflammation and oxidative stress are major factors in CAD. Epidemiologic studies have suggested that low levels of antioxidants are associated with increased risk for CAD and that increased intakes are protective.

Summary of Superior Benefits
PureWay-C is more rapidly taken-up and absorbed by cells than other forms of vitamin C. It is also more rapidly absorbed and more highly retained by the human body than other traditional forms of vitamin C. PureWay-C is directly associated with greater reduction of plasma levels of C-reactive protein and oxidized LDL in a human clinical study. It is a potent antioxidant and has significant free radical scavenging capabilities. Most importantly, it works faster and has greater beneficial effects than other forms of vitamin C, including more rapidly stimulating healthy neurons, more rapidly promoting wound healing, and more rapidly protecting the immune system.

PureWay-C is an all natural ingredient that is GMO-free, allergen-free, and suitable for both vegetarians and vegans. It also has received both Kosher and Halal certification.

YouthFlow uses PureWay-C throughout its entire line of nutraceuticals as our exclusive source of natural vitamin C.

PureWay-C® is a registered trademark of Innovation Laboratories, Inc. and is used here under license.

L-OptiZinc® - Super Zinc Antioxidant

Zinc, like iron, copper, and chromium is one of 16 essential trace minerals the body needs to keep healthy and fit. For people that are sick or out of shape, zinc may be the most precious metal of all. Zinc is essential for growth and development, reproduction, digestion, respiration, and for proper brain, nerve, vision and immune function. It is involved in numerous enzyme systems and is required for cardiovascular health, prostate health, and healthy testosterone levels.

L-OptiZinc® is a patented 1:1 complex of zinc and methionine, the amino acid best absorbed by the body. Studies show that L-OptiZinc® is absorbed better, retained longer and is more effective than other zinc supplements tested. L-OptiZinc®, standardized to 20% zinc, consists of zinc bound to the natural and more bioavailable “L” form of methionine (written as l- methionine) and as an antioxidant is the most potent form of zinc.

L-OptiZinc®:

	Promotes proper immune function
	Promotes proper nerve function
	Promotes reproduction, growth, and development
	Promotes proper digestion
	Promotes eye health
	Promotes prostate health
	Promotes healthy skin, hair and nails
	Helps prevent the effects of premature aging
	Promotes healthy testosterone levels

Research shows that a high-fiber meal can inhibit zinc absorption to less than 3% of the amount consumed. A 1992 study showed that OptiZinc®, the original methionine-bound zinc ingredient introduced in 1991, actually resists dietary fiber and phytate, and increases zinc absorption better than ordinary zinc supplements tested. In addition, unlike other zinc supplements, OptiZinc® and L-OptiZinc® will not adversely affect copper absorption.

Some zinc binding ligands, such as picolinic acid, have been shown to remove iron from cells and increase lead absorption. OptiZinc® and L-OptiZinc® will not remove iron from cells. In fact, a 1991 study showed that a combination of zinc and methionine actually inhibits lead absorption and reduces lead levels in the blood.

YouthFlow uses L-OptiZinc® throughout its entire line of nutraceuticals as our exclusive source of zinc.

L-OptiZinc® and OptiZinc® are trademarks of InterHealth Nutraceutical, Inc.
L-OptiZinc® brand l-methionine (U.S. Patents 4,764,633 and 5,278,329)

ChromeMate® - Potent, Safe & Effective

Chromium helps insulin metabolize fat, turn protein into muscle and convert sugar into energy. Chromium-activated insulin increases the amount of blood sugar available for energy production nearly twenty fold.

ChromeMate® is a unique, patented form of biologically active niacin-bound chromium called chromium nicotinate or polynicotinate that dramatically increases the effectiveness of chromium. Researchers have shown that ChromeMate® with its unique, patented oxygen-coordinated niacin-bound chromium is the safest and most potent form of chromium available as a dietary supplement.

ChromeMate® plays an important role in energy production, management of healthy blood sugar and cholesterol levels, and promotion of lean body mass and healthy weight control. Protected by three U.S. Patents and four international patents, ChromeMate® is the only niacin-bound chromium supplement with proven biological activity.

ChromeMate®:

	Helps maintain cholesterol and blood sugar levels that are already within the normal range
	Promotes cardiovascular health
	Promotes lean body mass
	Promotes healthy weight control

ChromeMate® plays an important role in energy production and promotion of lean body mass and healthy weight control. Studies have shown that ChromeMate® is absorbed and retained more than 600% greater than chromium chloride and 300% greater than chromium picolinate. Additional studies show that ChromeMate® significantly lowers serum cholesterol and improves HDL (good) cholesterol levels, lowers blood pressure, promotes lean body mass, helps reduce body weight and promotes proper insulin function in the body.

In the 1970’s, Dr. Walter Mertz showed that niacin-bound chromium strongly enhanced the action of insulin, while chromium bound to picolinic acid had virtually no effect. In 1994, researchers at the University of California, Davis, showed that ChromeMate® was absorbed and retained more than 300 percent better than chromium picolinate. A 1997 study showed that ChromeMate® plus modest exercise resulted in significant weight loss, while exercise plus chromium picolinate resulted in no weight loss. In fact, the study showed that chromium picolinate without exercise resulted in significant weight gain.

A 1995 study at Dartmouth and George Washington University showed that chromium picolinate caused significant chromosomal damage to hamster ovary cells (3 to 18-fold above control levels), while ChromeMate®, chromium chloride and niacin did not. According to the researchers, the damage was caused by the picolinate ligand because picolinic acid, in the absence of chromium, also resulted in chromosomal damage.

YouthFlow uses ChromeMate® throughout its entire line of nutraceuticals as our exclusive source of chromium.

ChromeMate® is a trademark of InterHealth Nutraceutical, Inc.
ChromeMate® brand niacin-bound chromium (U.S. Patents 4,923,855, 4,954,492 and 5,194,615

Betatene® Natural Mixed Carotenoids

A wealth of scientific research suggests that diets rich in fruits and vegetables may help reduce the risk of many chronic diseases. As a result, many public health organizations now recommend that people consume five to nine daily servings of fruits and vegetables, including those that are rich in carotenoids. Unfortunately, surveys have found that the majority of people do not consume optimal amounts of fruits and vegetables.

The most recent Continuing Survey of Food Intakes by Individuals (CSFII) found that:

	85% of Americans DO NOT meet both USDA (United States Department of Agriculture) fruit and vegetable recommendations on a daily basis
	60% of American DO NOT reach the “5 a day” minimum servings for fruits and vegetables combined
	Globally, the situation is very similar in all Western countries

Although supplements of carotenoids are not a substitute for a balanced diet including fruits and vegetables, they may help bridge the gap between what people should be eating as part of a healthy diet and what they actually do eat. Supplements provide a convenient and relatively inexpensive means of fortifying the diet, with a known dose of carotenoids in a highly bioavailable form (higher than fruit and vegetable sources.)

Carotenoids are antioxidants that quench free radicals, hazardous molecules that can damage cells and contribute to aging. In nature, carotenoids help protect plants from damaging effects of excess light. When people consume fruits and vegetables, studies suggest they benefit from the same protective antioxidant activities of carotenoids.

Betatene® natural mixed carotenoids contain several carotenoids derived from Dunaliella salina algae that are not only popular with consumers, but also well investigated by the scientific community. Betatene® provides a unique combination of important carotenoids that are found in many fruits and vegetables.

Betatene®:

	Contains beta-carotene, alpha-carotene, lutein, zeaxanthin, and cryptoxanthin
	Supplies several natural isomers (cis and trans) of beta-carotene, unlike the synthetic products, which contain mainly one isomer (mainly trans)
	Is also known as provitamin A because the human body converts beta carotene and alpha carotene to vitamin A
	Contains the microscopic alga Dunaliella salina that is cultivated in salt water from the clean and remote Southern and Indian Oceans of Australia

The algae in Betatene® are harvested mechanically without any chemical additives or solvents. The carotenoids are then extracted and formulated using only natural plant oils. Stability charts illustrate that Betatene® maintains its potency and stability over time.

Beta-carotene serves as an importance safe source of vitamin A, an essential nutrient. Supplements of vitamin A can cause toxicity in high doses, but beta-carotene is converted into vitamin A (retinol) only as the body requires it, preventing vitamin A toxicity.

YouthFlow uses Betatene® natural mixed carotenoids throughout its entire line of nutraceuticals as our exclusive source of provitamin A.

Betatene® is a registered trademark of Cognis Corporation.

Xangold® Natural Lutein Esters

Lutein esters and zeaxanthin esters are converted in the body to lutein and zeaxanthin, which appear to play crucial roles in the macula, the part of the eye responsible for detailed vision. Lutein and zeaxanthin form the macular pigment and may filter out harmful blue light and act as antioxidants to reduce free radical damage. Supplements and lutein rich foods can increase the macular pigment. Lutein and zeaxanthin are also present in the lens of the eye and may play a role in promoting good eye health.

Xangold® natural lutein esters contain lutein esters, small amounts of zeaxanthin esters and cryptoxanthin esters, which are extracted from marigold flowers (Tagetes erecta,) one of the richest sources of these compounds. Lutein esters are a source of lutein, commonly found in many fruits and vegetables.

Xangold®:

	Contains the same lutein esters as those found in yellow and orange fruits such as oranges, peaches, papayas, peppers, and squash
	Uses marigold flowers that are air-dried to prevent fermentation and degradation of the active ingredients
	Uses a patented process to carefully extract the lutein esters

Xangold® natural lutein esters go through a natural hydrolysis process in the human body that splits the ester bond releasing lutein from lutein esters. Research demonstrates that this lutein is chemically identical to the lutein supplied directly to the body from green leafy vegetables.

Human clinical studies prove that consumption of Xangold® results in elevated lutein in the blood, clearly demonstrating that hydrolysis of the lutein esters followed by lutein absorption takes place. A recent study in a prominent eye journal demonstrates a link between Xangold® natural lutein esters supplements and increased macular pigment density (Berendschot, T.T.J.M, et al.) Increased macular pigment density has been associated with maintaining eye health.

YouthFlow uses Xangold® natural lutein esters throughout its entire line of nutraceuticals as our exclusive source of lutein.

Xangold® is a registered trademark of Cognis Corporation.

Lyc-O-Mato® - Superior Natural Lycopene Complex

Lycopene is the red pigment, which gives the ripe tomato and watermelon their bright red color. It is present in much smaller amounts in other fruits and vegetables. Chemically, lycopene is a carotenoid with a unique structure, which consists of a long chain of conjugated double bonds, longer than in any other carotenoid. This configuration is responsible for lycopene’s ability to inactivate free radicals.

The carotenoids belong to a family of widespread natural pigments found in plants and animals. There are more than 600 known carotenoids in nature. All of them are synthesized only in plants, making plants the source of the carotenoids present in animals and in human beings. Only a few carotenoids are the natural components of our body and lycopene, followed by beta-carotene, is at the head of the list.

Free radicals are electro-chemically imbalanced molecules or atoms, which have impaired electrons in their systems. They acquire the missing electrons from their surroundings. This makes them highly aggressive chemicals, ready to react with cell components causing them permanent damage and triggering degenerative diseases such as cancer and arteriosclerosis. Oxygen derived free radicals are the most reactive species that attack our organism. These toxic chemicals are formed as by-products during oxidative cellular metabolism.

Scientists believe that excess oxidative stress plays an important role in the initiation and promotion of degenerative diseases. Exposure to environmental perils, such as smoking, pollution or irradiation, increases the oxidative stress beyond the ability of the organism’s defense system to cope with it. The natural mechanism that protects us from free radicals weakens with age. Therefore, the elderly, smokers and those exposed to environmental hazards are more susceptible to degenerative diseases.

Lycopene, because of its unique chemical structure, is the best-known biological quencher of free radicals, especially those derived from oxygen. The antioxidative and singlet oxygen quenching properties of lycopene are well documented. Recent findings indicate that lycopene plays an important part in the natural mechanism, which protects the organism from the damaging effect of free radicals, thus protecting us against the onset of degenerative diseases. Lycopene is present naturally in human plasma in greater amounts than any other dietary carotenoid.

Tomatoes, tomato products and tomato extracts, are the main sources of lycopene in our food. Other fruits and vegetables contribute only minor amounts of lycopene to our diet. Besides tomatoes, only watermelon, guava, pink grapefruit, and red oranges contain significant quantities of lycopene.

Lyc-O-Mato® is a natural tomato extract, very rich in lycopene and other synergistic phytonutrients that occur naturally in tomatoes and tomato extract, including phytofluene, phytoene, phytosterols, beta-carotene, and Vitamin E. Lyc-O-Mato® is the only natural tomato lycopene on the market using a patented process to yield superior bioavailability. The phytonutrients are carefully extracted and then preserved in natural tomato oil, allowing your body greater and faster access to the health benefits of tomato. Lyc-O-Mato® contains no genetically modified tomatoes, no synthetic lycopene, and no additives.

Lyc-O-Mato® Research:

	Epidemiology and human clinical trials demonstrate the prostate specific antioxidant action of Lyc-O-Mato®. {Journal of National Cancer Institute, Col. 94, No. 5, 391-397 (2002), Cancer Epidemiology Biomarkers & Prevention, 10:861-865 (2001)}
	Results of research from Harvard Medical School’s “Women’s Health Study” support earlier findings that a diet rich in tomato and tomato products helps to promote heart health. {Journal American College Nutrition 19,5:563-9(2000), Annual Meeting American College of Cardiology, (2002)}
	Dietary intake of tomato phytonutrients helps protect against photoxidative stress, which can damage skin tissue. {Journal of Nutrition, 131:1449-51, (2001)}
	The Beaver Dam Eye Study found that serum concentrations of lycopene supported eye health in aging eyes. {Achieves of Ophthalmology, 113:1518-1523, (1995)}
	New research out of Ben-Gurion University/Soroka Medical Center supports the growing evidence that lycopene, in combination with other tomato phytonutrients, may help maintain healthy breast tissue. {Levy Y, Sharoni J, unpub. Data, Soroka Medical Center, Israel, (2000)}

YouthFlow uses Lyc-O-Mato® throughout its entire line of nutraceuticals as our exclusive source of lycopene.

Lyc-O-Mato® is a registered trademark of LycoRed Natural Products Limited.

Lipoec® Alpha-Lipoic Acid

Isolated by biochemists in 1951, alpha-lipoic acid plays a fundamental role in nearly all types of living cells and may be considered essential for life itself. In humans and other mammals, alpha-lipoic acid serves as a component of several key enzyme complexes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. These enzymes are required in the “Krebs cycle,” which breaks down carbohydrate molecules and converts them to energy.

Alpha-lipoic acid, sometimes referred to as thioctic acid, is found in many foods including spinach, red meat, potato, broccoli, and tomato. It is also synthesized within the body.

Alpha-lipoic acid was long considered a growth factor for plants. Beginning in the 1950's, it was used medicinally in Europe to maintain the integrity of liver and nerve cells. It was not until the late 1980's that alpha-lipoic acid was recognized as an antioxidant with several unique properties. This discovery accelerated research, human trials, and scientific publications on alpha-lipoic acid – and heralded its rapidly growing acceptance among consumers and the medical community.

In Germany, where alpha-lipoic acid is prescribed, it has a long history of use helping people in certain populations maintain normal nerve function. At high doses, alpha-lipoic acid helps maintain normal blood sugar balance in certain populations, and it also helps protect the liver and other tissues.

Lipoec®:

	An extraordinary Antioxidant
	Helps maintain normal blood sugar balance in the body
	A proven cell protector
	Produced with exceptional quality

Lipoec® is marketed in partnership with the leading European supplier of alpha-lipoic acid. Manufacturing and process-control technology are of the highest pharmaceutical standards, yielding an exceptionally pure, consistent, and reliable product.

Alpha-lipoic acid has been described in scientific publications as the “ideal,” “universal,” and “metabolic” antioxidant. Without question, it is one of the most remarkable of all dietary antioxidants, but it does much more.

Many antioxidants function in only one type of environment, such as vitamin E in fatty tissues and vitamin C in watery milieu of cells. In contrast, alpha-lipoic acid is distinguished by its ability to function in both the water and fatty regions of cells. Combined with its other properties, this characteristic enables alpha-lipoic acid to function as one of the most diverse antioxidants.

Antioxidants quench hazardous molecules known as free radicals, which damage cells and contribute to the effects of aging. A powerful antioxidant in its own right, alpha-lipoic acid is routinely converted in the body to dihydrolipoic acid, another highly efficient antioxidant. Together, these two forms of alpha-lipoic acid neutralize a broad variety of free radicals.

To maintain health, the human body depends on a variety of cell-protecting antioxidants. However, the myriad roles of alpha-lipoic acid distinguish it from most other antioxidants.

After antioxidants quench free radicals, they are, in a manner of speaking, “used up.” Alpha-lipoic acid plays a central role in what researchers call the “antioxidant network.” Alpha-lipoic acid helps recycle and replenish vitamins E and C, gluthatione, and coenzyme Q10 – all-important antioxidants enabling the body to extend their biological life spans. Because of its distinctive chemical structure, alpha-lipoic acid also helps the body to produce more of the powerful antioxidant, glutathione. In addition, research has also shown that antioxidants are synergistic and, as a team, have greater free radical quenching properties than individual antioxidants. These exceptional qualities make alpha-lipoic acid the universal antioxidant.

YouthFlow uses Lipoec® throughout its entire line of nutraceuticals as our exclusive source of alpha-lipoic acid.

Lipoec® is a registered trademark of Cognis Corporation.

ActiVin® - Powerful Grape Seed Antioxidant

For years, scientists have studied the phenomenon known as the “French Paradox.” The French have a diet filled with saturated fat and cholesterol, yet they have the lowest rate of heart disease of any western society – nearly half that of the United States. Why? Some scientists believe the answer lies in the red wine the French drink – specifically, the polyphenolic bioflavonoids concentrated inside the grape seeds, which end up in the wine. In fact, that is why some experts believe that red wine is more healthful than white, since red wine is fermented with the seeds while white wine is not.

The polyphenolic bioflavonoids in grape seeds, which include oligomeric proanthocyanidins or “OPC’s”, are some of the most powerful antioxidants yet discovered. Studies have shown that these OPC’s can help prevent free radical formation, which may be an important factor of premature aging. Proanthocyanidins are potent antioxidant nutrients that can help neutralize harmful free radicals and also help maintain normal blood platelet function in the body. Platelets help to repair nicks and tears in our blood vessels that occur every day. Sometimes blood platelets become too sticky and build up on artery walls, which may increase risks of heart attacks and strokes. These antioxidants can help blood platelets to function regularly and thus promote cardiovascular health.

Antioxidants are powerful compounds that neutralize free radicals and help you maintain a healthy, active life. While the body produces some antioxidants, others, including vitamins C, E and beta-carotene, as well as polyphenolic bioflavonoids, must be consumed in our daily diet.

ActiVin® is an all natural red grape seed extract and is a highly concentrated source of OPC’s, which delivers the power of these polyphenolic bioflavonoids in a convenient, alcohol-free form to help your body fight free radicals and the damage they cause. Studies have shown that ActiVin® is a super antioxidant – far more powerful than vitamins C, E, and beta-carotene. It is made by a unique, patented process called ActiPure™, which uses only natural ingredients, the same ingredients found in red wine: water and ethanol. Other grape seed extracts typically use potentially dangerous chemicals such as acetone, methylene chloride and toluene, which can leave residues and strip away many of the nutrients that the ActiVin® process retains. Not only is ActiVin® safe and healthy to consume, it’s environmentally friendly to produce, as no toxic chemicals are flushed down the drain and no trees are cut down for their bark. ActiVin® is the most extensively studied grape seed extract on the market today with more than 90 scientific publications, abstracts and presentations reporting its health benefits. It is also the only grape seed extract to go through the rigorous review process to secure and receive GRAS (Generally Recognized As Safe) approval. The US Patent office recently issued two separate patents for the use of ActiVin® grape seed extract for cardiovascular benefit.

YouthFlow uses ActiVin® throughout its entire line of nutraceuticals as our exclusive source of grape seed extract.

ActiVin® is a trademark of San Joaquin Valley Concentrates, Inc.

OptiBerry® Multiple Berry Anthocyanin Extract

Anthocyanins are common components of fruits and vegetables, in particular berries, which provide pigmentation (color) and serve as natural antioxidants. A growing body of scientific evidence has shown that anthocyanin-rich berries possess numerous potential health benefits and protective effects, including antioxidant activity. Anthocyanins also help maintain DNA integrity.

Anthocyanins differ from other natural flavonoids in the range of colors that can be derived from them and by their ability to form resonance structures by changes in pH. The positively charged oxygen atom in the anthocyanin molecule makes it a more potent hydrogen-donating antioxidant compared to oligomeric proanthocyanidins (OPC's) and other flavonoids.

OptiBerry® is a unique, proprietary blend of six standardized berry extracts rich in biologically active anthocyanins (patent-pending) formulated and tested to promote optimum potency, efficacy, antioxidant activity and bioavailability. OptiBerry® contains standardized levels of anthocyanins, including malvidin, cyanidin, delphinidin and petunidin, in biologically active ratios.

OptiBerry®:

	Promotes healthy brain function and mental clarity
	Promotes healthy vision
	Promotes cardiovascular health
	Promotes healthy skin
	Promotes urinary tract health
	Helps maintain blood sugar levels that are already within the normal range
	Helps prevent the effects of premature aging

Properties	OptiBerry®	Wild Blueberry	Wild Bilberry	Cranberry	Elderberry	Raspberry Seed	Strawberry
Antioxidant Activity
Cardiovascular Protection
Blood Sugar Support
Brain Function & Mental Clarity
Anti-Aging Properties
Urinary Tract Health
Healthy Vision
Skin Health

OptiBerry® (patent-pending) is the result of extensive scientific research, which methodically evaluated key functional parameters, including ORAC (antioxidant activity), VEGF (anti-angiogenic activity), bioavailability and safety of numerous individual berry extracts. Based on these findings, more than 20 combinations of individual berry extracts were formulated and evaluated to determine the safest and most efficacious combination. Of the combinations tested, one stood out above all others, OptiBerry®, a proprietary blend of wild blueberry, strawberry, cranberry, wild bilberry, elderberry and raspberry seed extracts, which demonstrated superior safety, bioavailability, antioxidant and anti-angiogenic activity.

YouthFlow uses OptiBerry® throughout its entire line of nutraceuticals as our exclusive source of multiple berry anthocyanin extract.

OptiBerry® is a registered trademark of InterHealth Nutraceutical, Inc.

Super CitriMax® Full Strength – Nature’s Perfect Diet Ingredient

CitriMax® and new higher potency Super CitriMax® (patent-pending) are all natural, safe and effective plant extracts used as diet ingredients. Extracted from the South Asian fruit Garcinia cambogia, CitriMax® and Super CitriMax® contain standardized levels of (–) hydroxycitric acid (HCA), which has been clinically shown to suppress appetite and inhibit fat production, without stimulating the central nervous system.

CitriMax® and new higher potency Super CitriMax® work by inhibiting the enzymes that convert carbohydrates into fat. If not utilized for energy, carbohydrates are converted into fat and stored in the body. CitriMax® and Super CitriMax® inhibit the conversion of carbohydrates into fat and promotes an increase in the formation of stored energy as glycogen. This also signals the brain to turn off hunger signals. New studies show that full strength doses of Super CitriMax® increases brain serotonin levels, a neurotransmitter involved in appetite regulation, and decreases levels of leptin, a marker for the gene that regulates body weight. No other HCA product has been shown to do this.

These ingredients work naturally without stimulating the central nervous system. They are also non-habit forming and will not cause sleeplessness, nervousness or rapid heart rate associated with diet stimulants such as Ma-Huang (ephedra) or PPA (Dexatrim®). CitriMax® and Super CitriMax® are manufactured under strict laboratory-controlled procedures to ensure optimum potency, purity and efficacy. They are also more soluble and better absorbed than other HCA products, and are low in HCA lactone, a less effective form of HCA found in many generic HCA products. CitriMax® is InterHealth’s original HCA diet ingredient introduced in 1994. Standardized to 50% (–) hydroxycitric acid, regular CitriMax® consists of HCA bound to calcium in a stable ~70% soluble form. Super CitriMax® consists of HCA bound to calcium and potassium in a stable, highly bioavailable 100% soluble form standardized to 60% (–) hydroxycitric acid (patent-pending). As an added bonus, the potassium in Super CitriMax® is an important mineral necessary for energy production and fat metabolism. Super CitriMax® is also tasteless, colorless and odorless in solution, which makes it well suited for use in beverages.

In a 90-patient, randomized, double blind, placebo-controlled human clinical study, researchers at Georgetown University Medical Center showed that full strength doses of Super CitriMax® is a powerful all natural diet aid that can help:

	Increase serum serotonin levels and decrease appetite
	Decrease serum leptin levels and reduce body weight
	Inhibit fat synthesis and increase fat "burning”
	Helps maintain cholesterol and blood sugar levels that are already within the normal range
	Reduce Body Mass Index (an indicator of healthy body weight)

Super CitriMax® Full Strength refers to the HCA potency, bioavailability and dosage used in the Super CitriMax® human clinical study. HCA has been sold as a safe, all natural diet ingredient for years with mixed results. The reason isn’t really a mystery – all HCA products are not created equal. They vary according to potency, bioavailability and dosage, each of which is critical to effectiveness. Taken together, the 60% HCA potency, superior bioavailability and clinically tested doses used in the Super CitriMax® clinical study has resulted in a new generation diet product like no other…new Super CitriMax® Full Strength, a powerful patent-pending diet ingredient.

YouthFlow uses Super CitriMax® Full Strength in its nutraceutical line as our exclusive source of standardized hydroxycitric acid (HCA).

Super CitriMax® is a trademark of InterHealth Nutraceutical, Inc.

Protykin® - Natural Plant Estrogens

Phytoestrogens are substances in plants that mimic the effects of human estrogen in the body. Their chemical structures are similar to human estrogen and capable of binding to estrogen receptors, forming active phytoestrogen-receptor complexes capable of inducing estrogen-like activity. In fact, phytoestrogens have been present in the human diet for thousands of years. They are thought to be a source of natural estrogens the human body has come to rely on to supplement the declining levels of estrogen naturally produced by a women's body in midlife and beyond.

Protykin® is a high potency 200:1 standardized extract of Polygonum cuspidatum (root), a powerful antioxidant and cardioprotectant that contains 50% phytoestrogens (natural plant estrogens). As a phytoestrogen, Protykin® helps maintain normal estrogen activity, reduce hot flashes, balance mood swings and promote healthy bone density. Derived from the root of Polygonum cuspidatum, an herb used in traditional Chinese medicine, Protykin® contains more than 1,000-times the amount of the same antioxidant ingredient in red wine that is believed to promote cardiovascular health and reduce the effects of premature aging.

Protykin®:

	Promotes normal estrogen activity
	Reduces hot flashes
	Balances mild mood swings
	Promotes healthy bones
	Promotes cardiovascular health
	Helps prevent the effects of premature aging

Protykin® contains powerful phytoestrogens that have been shown to bind to the Human Estrogen Receptor and enhance estrogen-like activity in the body, without causing any of the side effects associated with synthetic hormone replacement therapy (HRT). In fact, research suggests that the phytoestrogens in Protykin® are the same substances in red wine responsible for the cardiovascular health benefits associated with its consumption. These phytoestrogens also have the added benefit of being antioxidants, which provides cellular protection against free-radical attack, protecting the body against environmental pollutants and helps prevent the effects of premature aging.

The phytoestrogens in Protykin® are structurally very similar to Diethylstilbestrol (DES), a synthetic form of estrogen commonly used in Hormone Replacement Therapy. However, these phytoestrogens do not produce any of the side effects associated with DES, such as liver and gallbladder disease, high blood pressure, stroke, heart attack and certain types of cancer.

New Research to Focus on Cardiovascular Benefits
InterHealth Nutraceuticals has received a $100,000 research grant from the National Institutes of Health (NIH) to study the potential benefits of resveratrol as a pharmacological preconditioning agent. Protykin®, a standardized Polygonum cuspidatum plant extract containing 50 percent trans-resveratrol, possesses antimutagenic, antibacterial and gastroprotectant properties.

InterHealth will partner with the University of Connecticut School of Medicine (Farmington, Connecticut) to conduct this research. Dr. Debasis Bagchi, Vice President of Research and Development for InterHealth, will serve as the primary investigator on the project. Professor Dipak K. Das, Ph.D., a renowned cardiovascular biologist and director of cardiovascular research at the University of Connecticut School of Medicine, will jointly spearhead the project to evaluate the advanced cardioprotective mechanisms of Protykin and its possible cardiovascular benefits to humans. It is expected the research will be completed by the end of 2004, with presentation and publication of the results expected in 2005.

“InterHealth is proud to receive this grant from the prestigious NIH,” stated Dr. Bagchi.“ Our team looks forward to continuing our exploration of the cardioprotective benefits of Protykin®. Cardiovascular disease is the leading cause of death in the U.S. and we hope this research can help the millions of people at risk for it.”

Founded in 1887, the National Institutes of Health today is one of the world's foremost medical research centers, and the federal focal point for medical research in the United States. The NIH, comprising 27 separate institutes and centers, is one of eight health agencies of the Public Health Service, which is part of the U.S. Department of Health and Human Services.
(Source, InterHealth Nutraceuticals, Inc., January 16, 2004)

YouthFlow uses Protykin® in its nutraceutical line as our exclusive source of standardized Polygonum cuspidatum (root) extract.

Protykin® is a trademark of InterHealth Nutraceutical, Inc.

GlucoFit™ - Blood Sugar Support

The first diagnosis of diabetes dates back to Greece, 2000 years ago. Blood sugar balances, in general, and diabetes, in particular, have been the subjects of increasing scientific study. Diabetes affects 16 million people in the United States alone and is the fourth leading cause of death. Diabetes is also the principal cause of blindness in adults and the most common cause of kidney failure and attendant problems of kidney dialysis or kidney transplantation.

Type I diabetes, often called juvenile diabetes, is insulin dependent and affects only 5% of the diabetic population, usually children or young adults under the age of 30. Type II diabetes, or non-insulin dependent diabetes, usually develops in adults over the age of 40, and it can run in families. In recent years, there has been an increase in the incidence of Type II diabetes.

People with Type II diabetes often show no symptoms. The factors promoting the incidence of Type II diabetes include an aging population and increased reliance on rich and processed foods, a sedentary life style and lack of regular exercise, in addition to hereditary factors.

GlucoFit™ is a formulation of Lagestroemia speciosa L., a “medicinal” plant commonly grown in Asia. The leaves contain high levels of corosolic acid, the active ingredient. GlucoFit™ is a patented phyto-formulation that has a natural ability to maintain blood sugar levels that are already within the normal range, which in turn stabilizes body weight.

In a recent study, GlucoFit™ was determined safe for non-diabetics. It is a clinically proven product for activating cell glucose-transporter “shuttles.” This action balances blood glucose levels naturally. GlucoFit™ also exhibits a memory effect of blood glucose maintenance even after supplementation is ceased. The clinical study found both normal subjects and Type II diabetics experience an average weight loss of up to three pounds per month with GlucoFit™ supplementation.

This randomized, double blind, crossover clinical study found that subjects experienced a sharper decline in blood glucose levels after an evening meal. In fact, their blood glucose levels resembled a normoglycemic profile with GlucoFit™ supplementation. Research has shown maintaining an ideal blood glucose level is a winning strategy for many health concerns. Adding weight loss to the package only “sweetens” the deal.

YouthFlow uses GlucoFit™ in its nutraceutical line as our exclusive source of standardized corosolic acid extract.

GlucoFit™ is a registered trademark of Soft Gel Technologies, Inc.